SNAI1, SNAI2, SNAI3 (AA 188-264) antibody

Catalog No. ABIN685597

This Rabbit Polyclonal antibody specifically detects in ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) and WB. It exhibits reactivity toward Human and Rabbitand has been mentioned in 1 publication.

Quick Overview for SNAI1, SNAI2, SNAI3 (AA 188-264) antibody (ABIN685597)

Target: SNAI1, SNAI2, SNAI3

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Application: ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Product Details

Binding Specificity: AA 188-264

Cross-Reactivity: Human, Rabbit

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Snail

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Takahashi, Akamatsu, Yagami, Hasegawa, Ohgo, Abe, Iwata, Arima, Mizutani, Nakata, Matsunaga: "Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea." in: The Journal of dermatology, Vol. 40, Issue 9, pp. 720-5, (2013) (PubMed).

Target Details

Target: SNAI1, SNAI2, SNAI3

Background:

Synonyms: dJ710H13.1, Protein sna, Protein snail homolog, SLUGH2, SNA, Sna protein, SNAH, SNAI1, Snail homolog 1 Drosophila, Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, dJ710H13.1, SNAIL, SNAIL1, Protein sna, SLUG, WS2D, SLUGH, SLUGH1, SNAIL2, SMUC, SNAIL3, ZNF293, Zfp293

Background: The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression.

Molecular Weight: 29kDa

Gene ID: 6615, 6591, 333929

UniProt: Q02085, P97469, Q9QY31